Overland pharmaceuticals- Immune Cell Therapy_ Scientist/Senior Scientist
Position: Immune Cell Therapy_ Scientist/Senior Scientist
Location: On-site in the San Francisco Bay area
Department: Cell Therapy Platform Research
Report to: Director Immune Cell Therapy
Our Company
Founded in 2020, Overland Pharmaceuticals is a cross-border platform company focusing on advanced modalities through strategic partnering and in-house R&D. Seeded by Hillhouse Capital with access to the global innovation and biopharma ecosystem, Overland is building an initial oncology portfolio of first-in-class allogeneic cell therapies and ADC programs through strategic partnerships with Allogene and ADC Therapeutics. In particular, Overland is establishing GMP manufacturing facilities and expanding our cell therapy platform to focus on next-generation iPSC-based cell therapies to serve global patients.
We are seeking a highly motivated Scientist/Senior Scientist to join our research team. The successful candidate will play a key role in building an industry-leading iPSC platform to develop life-saving allogeneic cell therapies. Overland Pharmaceuticals offers boundless opportunities, supportive environment, competitive compensation and comprehensive benefits.
Essential Duties and Responsibilities
· Serve as internal immunology expert to develop allogeneic immune cell therapies
· Develop flow assays for phenotypic analysis of iPSC-derived NK and T cells.
· Develop target cell killing assays for functional analysis of iPSC-derived NK and T cells.
· Develop benchmark assays using primary NK and T cells.
· Develop reagents and assays to support CAR binder generation and characterization.
- Maintain organized, detailed records to support internal documentation and regulatory requirements.
- Manage lab operations, such as equipment maintenance and ordering of consumables.
Skills and Competencies
- Must have hands-on experience with human immune cell isolation, phenotypic and functional analysis.
- Ex vivo activation, viral transduction and expansion experience is required.
- Ex vivo T or NK cell activity analysis is required. Experience using Incucyte is preferred.
- Experience in ELISA or similar assays to measure cytokines is required.
- In vivo CAR-NK or CAR-T function assay using NSG mice is preferred.
- Knowledge and experience with allogeneic CAR-NK or CAR-T is required.
- Knowledge and experience with gamma-delta T cells is desirable.
- Proficiency in designing, implementing, and troubleshooting multi-color flow experiments is required.
- Able to work independently as well as in a team with diverse background.
- Able to collect, analyze and present data to the research and management teams.
- Strong written and verbal communication skills. CAR-NK or CAR-T related publication is preferred.
- A can-do attitude and an ability to adapt to evolving priorities. Able to travel when needed.
Educational Requirement
- PhD or MS in Immunology, Bioengineering, Cell Biology, Molecular Biology, or related fields. Title and compensation commensurate with skills, achievements, experience and education.